RICHARD HANS GOMER

TITLE: Professor

ADDRESS: Department of Biochemistry and Cell Biology

MS-140

Rice University

Houston, TX 77251-1892

EMAIL: richard@bioc.rice.edu

PHONE: Lab: (713) 348-4872 Fax: (713) 348-5154 Home: (713) 668-4091

EDUCATION: Pomona College, Claremont, California, B.A. (Physics), l977

California Institute of Technology, Pasadena, California, Ph.D. (Biology), l983

AWARDS: National Merit Scholarship Letter of Commendation, 1972

Pomona College Tileston Physics Prize, 1977

NIH Predoctoral Traineeship, 1977-1982

NIH Postdoctoral Fellowship, September l983-August l986

American Cancer Society California Chapter Senior Postdoctoral Fellowship, September 1986-August 1988

Outstanding Associate 1990-91, Hanszen College, Rice University

Exemplary Contributions Award, Premedical Society, Rice University, 1998

RESEARCH AND PROFESSIONAL EXPERIENCE:

1. Electronics Construction, Enrico Fermi Institute, University of Chicago, Summer, 1975

2. Design and construction of a computer-driven large screen display, Biophysics/Theoretical Biology, University of Chicago, Summer, 1976

3. Visiting Scientist, Carnegie Institution of Washington, Mount Wilson and Las Campanas Observatories, 3/1983-7/1983

4. Postdoctoral Fellow, Biology Department, University of California, San Diego, 9/l983-9/l988

5. Assistant Professor of Biochemistry and Cell Biology, Rice University, 9/1988-6/1994; Associate Professor, 7/1994-6/2000; Professor, 7/2000-present

6. Adjunct Assistant Professor of Cell Biology, Baylor College of Medicine, 4/1990-8/2005

7. Consultant, Terrapin Diagnostics, 1986-1999

8. Assistant Investigator, Howard Hughes Medical Institute, 6/1990-6/1996; Associate Investigator, 7/1996-8/2000; Investigator, 9/2000-8/2005

9. Member, NIH Surgery, Radiology and Bioengineering special study section 8, 4/2001 – 8/2003

10. Science Advisory Board member, Trellis Bioscience, 9/2004- present

11. Co-founder and Science Advisory Board member, Medior BioPharm, 5/2006-present

TEACHING EXPERIENCE:

Homework grader for second and third year undergraduate Physics courses, Pomona College, 1975-1977

Teaching Assistant for first year undergraduate Physics lab section, Pomona College, 1975-1977

Teaching Assistant for graduate level Electrophysiology course, Caltech, 1977-1980

Teaching Assistant for undergraduate Cell Biology course, Caltech, 1979-1982

Biochem 361/501 - General Biochemistry, Rice, 50% of lectures, 1989

Biochem 362, 502 - General Biochemistry, Rice, 50% of lectures, 1989

Bios 301 - Biochemistry, 51% of lectures, Rice, 1990-2001

Biochem 367S - Experimental Biochemistry, 17% of lectures, Rice, 1990

Bios 575 - Introduction to Research in Biochemistry and Cell Biology, 1 lecture, 1990-present

Bios 311 - Lab Module in Biochemistry, Rice, 17% of lectures, 1991

Bios 312 - Molecular Biology Lab Module, Rice, 30% of lectures for 2 separate sections, 1992-95

Bios 313 - Sequencing Lab Module, Rice, 30% of lectures, 1992-97

Bios 590 - Special Topics in Biochemistry & Cell Biology, Rice, 50% of lectures, 1995

Bios 590 - Special Topics: Mammalian Morphogenetic Factors, Rice, 50% of lectures, 1997

Bios 318 - Lab Module in Electron Microscopy, 40% of lectures, 1998, 1 lecture 1999 - 2002

Bios 588 - Graduate seminar, 16% of lectures, 1998; 50% of lectures, 1999-present

Bios 202 – Introductory Biology, 50% of lectures, 2002-present

PUBLICATIONS:

Astronomy:

1. Petro, L., Bradt, H., Lamb, D., Kelley, R., Jacobs, S., Meiksin, A., Horne, K., and Gomer, R. SAS-3 observations of rapid X-ray variability of Sco-X1 and observations of correlated optical variability. Bull. Amer. Astron. Soc. 11, 464 (1979).

2. Petro, L., Jacobs, S., Schaeffer, B., Bradt, H., Kelley, R., Horne, K., and Gomer, R. Power spectrum analysis of Sco-X1 flaring. Bull. Amer. Astron. Soc. 11, 795 (1979).

3. Horne, K., and Gomer, R. SS433. IAU Circular No. 3379 (1979).

4. Horne, K., and Gomer, R. Phase variability in the rapid oscillation of SS Cygni. Astrophysical Journal 237, 845-849 (1980).

5. Lanning, H.H., Horne, K., and Gomer, R. Lanning 10. IAU Circular No. 3567 (1981).

6. Petro, L.D., Bradt, H.V., Kelley, R.L., Horne, K., and Gomer, R. Rapid X-ray and optical flares from Scorpius X-1. Astrophysical Journal 251, L7-L11 (1981).

7. Horne, K., Lanning, H.H., and Gomer, R. A first look at the cataclysmic variable Lanning 10. Astrophysical Journal 252, 681-689 (1982).

8. Jensen, K.A., Cordova, F.A., Middleditch, J., Mason, K.O., Grauer, A.D., Horne, K., and Gomer, R. The correlated X-ray and optical time variability of TT Arietis. Astrophysical Journal 270, 211-225 (1983).

9. Welsh, W.F., Horne, K., and Gomer, R. On the location of the oscillations in AE Aquarii. Astrophysical Journal 410, L39-L42 (1993).

10. Martell, P.J., Horne, K., Price, C.M., and Gomer, R.H. Taking the pulse of DQ Herculis. Astrophysical Journal 448, 380-394 (1995).

11. Welsh, W.F., Horne, K., and Gomer, R. A study of the absorption lines from the donor star in the exotic cataclysmic variable AE Aquarii. Monthly Notices of the Royal Astronomical Society 275, 649-670 (1995).

12. Welsh, W.F., Horne, K., and Gomer, R.H. Doppler signatures of Ha flares in AE Aquarii. Monthly Notices of the Royal Astronomical Society 298, 285-302 (1998).

13. Bloom, J.S., Frail, D.A., Kulkarni, S.R., Djorgovski, S.G., Halpern, J.P., Marzke, R.O., Patton, D.R., Oke, J.B., Horne, K.D., Gomer, R., Goodrich, R., Campbell, R., Moriarty-Schieven, F.H., Redman, R.O., Feldman, P.A., Costa, E., Masetti, N. The discovery and broad-band follow-up of the transient afterglow of GRB 980703. Astrophysical Journal 508, L21-L24 (1998).

14. Steeghs, D., O’Brien, K., Horne, K., Gomer, R., and Oke, B. Emission line oscillations in the dwarf nova V2051 Ophiuchi. Monthly Notices of the Royal Astronomical Society 323, (2) 484-496 (2001).

15. O’Brien, K., Horne, K., Boroson, B., Still, M., Gomer, R., Oke, J.B., Boyd, P., and Vrtilek, S.D. Keck II spectroscopy of mHz quasi-periodic oscillations in Hercules X-1. Monthly Notices of the Royal Astronomical Society 326, 1067-1075 (2001).

16. Skidmore, W., Pearson, K.J., O’Brien, K., Horne, K., and Gomer, R. Fireballs and oscillations in AE Aqr., The Physics of Cataclysmic Variables and Related Objects: ASP Conference Series 261, 169-170 (2002)

17. Skidmore, W., O’Brien, K., Horne, K., Gomer, R.H., Oke, J.B., and Pearson, K.J. High speed Keck spectroscopy of flares and oscillations in AE Aquarii. Monthly Notices of the Royal Astronomical Society 338, 1057-1066 (2003).

18. O’Brien, K., Horne, K, Gomer, R.H., Oke, J.B., and van der Klis, M. High-speed Keck II and RXTE spectroscopy of Cygnus X-2: (I) Three X-ray components revealed by spectral variability. Monthly Notices of the Royal Astronomical Society. 350, 587-595. (2003)

19. Skidmore, W., Gomer, R.H, Horne, K., O’Brien, K., Oke,.B. and Pearson, K.J. High Speed Keck Spectroscopy of Flickering in AM Her. IAU Colloquium 190 on Magnetic Cataclysmic Variables: ASP Conference Series, Vol. 315, 163-169 (2004).

Biology:

1. Gomer, R.H., and Lazarides, E. The synthesis and deployment of filamin in chicken skeletal muscle. Cell 23, 524-532 (1981).

2. Wang, C., Gomer, R.H., and Lazarides, E. Heat shock proteins are methylated in avian and mammalian cells. Proc. Natl. Acad. Sci. USA 78, 3531-3535 (1981).

3. Gomer, R.H., and Lazarides, E. Switching of filamin polypeptides during myogenesis in vitro. J. Cell Biol. 96, 321-329 (1983).

4. Gomer, R.H., and Lazarides, E. Highly homologous filamin polypeptides have different distributions in slow and fast muscle fibers. J. Cell Biol. 97, 818-823 (1983).

5. Reymond, C.D., Gomer, R.H., Mehdy, M.C., and Firtel, R.A. Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein. Cell 39, 141-148 (1984).

6. Gomer, R.H., Datta, S., and Firtel, R.A. Sequencing homopolymer regions. Focus 7, 6-7 (1985).

7. Gomer, R.H., Datta, S., Mehdy, M., Crowley, T., Sivertson, A., Nellen, W., Reymond, C., Mann, S., and Firtel, R.A. Regulation of cell-type specific gene expression in Dictyostelium. Cold Spring Harbor Symp. Quant. Biol. 50, 801-812 (1985).

8. Crowley, T.E., Nellen, W., Gomer, R.H., and Firtel, R.A. Phenocopy of discoidin I- minus mutants by anti-sense transformation in Dictyostelium. Cell 43, 633-641 (1985).

9. Datta, S., Gomer, R.H., and Firtel, R.A. Spatial and temporal regulation of a foreign gene by a prestalk specific promoter in transformed Dictyostelium discoideum. Mol. Cell. Biol. 6, 811-820 (1986).

10. Reymond, C.D., Nellen, W., Gomer, R.H., and Firtel, R.A. Regulation of the Dictyostelium ras gene during development and in transformants. In Progress in Developmental Biology, Part A (H.C. Slavkin, Ed.), Alan R. Liss, New York, pp. 17-21 (1986).

11. Gomer, R.H., Armstrong, D., Leichtling, B.H., and Firtel, R.A. cAMP induction of prespore and prestalk gene expression in Dictyostelium is mediated by the cell-surface cAMP receptor. Proc. Natl. Acad. Sci. USA 83, 8624-8628 (1986).

12. Reymond, C.D., Gomer, R.H., Nellen, W., Theibert, A., Devreotes, P., and Firtel, R.A. Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants. Nature 323, 340-343 (1986).

13. Gomer, R.H., Datta, S., and Firtel, R.A. Cellular and subcellular distribution of a cAMP-regulated prestalk protein and prespore protein in Dictyostelium discoideum: A study on the ontogeny of prestalk and prespore cells. J. Cell Biol. 103, 1999-2015 (1986).

14. Gomer, R.H., and Firtel, R.A. Tissue morphogenesis in Dictyostelium discoideum . In Molecular Approaches to Developmental Biology (R.A. Firtel and E.H. Davidson, Eds.). Alan R. Liss, New York. pp. 373-383 (1987).

15. Datta, S., Mann, S.K.O., Hjorth, A., Gomer, R.H., Howard, P., Armstrong, D., Reymond, C., Silan, C., and Firtel, R.A. cAMP-regulated gene expression during Dictyostelium development is mediated by the cell-surface cAMP receptor. In Genetic Regulation of Development, 45th Symposium for the Society of Developmental Biology (W.F. Loomis, Ed.). Alan R. Liss, New York. pp. 33-61 (1987).

16. Gomer, R.H. A strategy to study development and pattern formation: Use of antibodies against products of cloned genes. In Methods in Cell Biology (J.A. Spudich, Ed.). Academic Press, New York, pp. 471-487 (1987).

17. Gomer, R.H., and Firtel, R.A. Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase. Science 237, 758-762 (1987).

18. Price, M.G. and Gomer, R.H. Mitoskelin: A mitochondrial protein found in cytoskeleton preparations. Cell Motility and the Cytoskeleton 13, 274-287 (1989).

19a. Kauvar, L.M., Cheung, P.Y.K., Gomer, R.H., and Fleischer, A.A., Paralog chromatography. Biotechniques 8, 204-209 (1990).

19b. Kauvar, L.M., Cheung, P.Y.K., Gomer, R.H., and Fleischer, A.A., Paralog chromatography. BioChromatography 5, 22-26 (1990). (Explanation: James Ellingboe, the editor of both BioTechniques and BioChromatography, after acceptance of 19a, requested that he be able to reprint it as 19b.)

20. Gomer, R.H., Yuen, I.S., and Firtel, R.A. A secreted 80x103 Mr protein mediates sensing of cell density and the onset of development in Dictyostelium. Development 112, 269-278 (1991).

21. Yuen, I.S., Taphouse, C., Halfant, K., and Gomer, R.H. Regulation and processing of a secreted protein that mediates sensing of cell density in Dictyostelium. Development 113, 1375-1385 (1991).

22. Jain, R., Murtagh, J.J.Jr., Gomer, R.H. Increasing specificity and yield from the PCR-RACE technique. BioTechniques 12, 58-59 (1992).

23. Jain, R., Yuen, I.S., Taphouse, C.R., and Gomer, R.H. A density sensing factor controls development in Dictyostelium. Genes & Development 6, 390-400 (1992).

24. Clarke, M., Dominguez, N., Yuen, I.S., and Gomer, R.H. Growing and starving Dictyostelium cells produce distinct density-sensing factors. Dev. Biol. 152, 403-406 (1992).

25. Schatzle, J., Bush, J., Dharmawardhane, S., Firtel, R.A., Gomer, R.H., and Cardelli, J. Characterization of the signal transduction pathways and cis-acting DNA sequence responsible for the transcriptional induction during growth and development of the lysosomal a-mannosidase gene in Dictyostelium discoideum. J. Biol. Chem. 268, 19632-19639 (1993).

26. Price, M.G., and Gomer, R.H. Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins. J. Biol. Chem. 268, 21800-21810 (1993).

27. Price, M.G., Caprette, D.R., and Gomer, R.H. Different temporal patterns of expression result in the same type, amount and distribution of filamin (ABP) in cardiac and skeletal myofibrils. Cell Motil. Cytoskel. 27, 248-261 (1994).

28. Jain, R., and Gomer, R.H. A developmentally regulated cell surface receptor for a density-sensing factor in Dictyostelium. J. Biol. Chem. 269, 9128-9136 (1994).

29. Yuen, I.S., and Gomer, R.H. Cell density-sensing in Dictyostelium by means of the accumulation rate, diffusion coefficient and activity threshold of a protein secreted by starved cells. J. Theoretical Biology 167, 273-282 (1994).

30. Gomer, R. Knowing that you’re among friends. Current Biology 4, 734-735 (1994).

31. Yuen, I.S., Jain, R., Bishop, J.D., Lindsey, D.F., Deery, W.J., Van Haastert, P.J.M., and Gomer, R.H. A density-sensing factor regulates signal transduction in Dictyostelium. J. Cell Biol. 129, 1251-1262 (1995).

32. Clay, J., Ammann, R., and Gomer, R.H. Initial cell-type choice in a simple eukaryote: Cell-autonomous or morphogen-gradient dependent? Dev. Biol. 172, 665-674 (1995).

33. Clarke, M. and Gomer, R.H. PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium. Experientia 51, 1124-1134 (1995).

34. Gomer, R.H. and Ammann, R. A cell-cycle phase-associated cell-type choice mechanism monitors the cell cycle rather than using an independent timer. Dev. Biol. 174, 82-91 (1996).

35. Spann, T.P., Brock, D.A., Lindsey, D.F., Wood, S.A., and Gomer, R.H. Mutagenesis and gene identification in Dictyostelium by shotgun antisense. Proc. Natl. Acad. Sci. USA 93, 5003-5007 (1996).

36. Brock, D.A., Buczynski, F., Spann, T.P., Wood, S.A., Cardelli, J., and Gomer, R.H. A Dictyostelium mutant with defective aggregate size determination. Development 122, 2569-2578 (1996).

37. Van Haastert, P.J.M., Bishop, J.D., and Gomer, R.H. The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium. J. Cell Biol. 134, 1543-1549 (1996).

38. Wood, S.A., Ammann, R.R., Brock, D.A., Li, L., Spann, T.P., Gomer, R.H. RtoA links initial cell type choice to the cell cycle in Dictyostelium. Development 122, 3677-3685 (1996).

39. Brazill, D.T., Gundersen, R. and Gomer, R.H. A cell-density sensing factor regulates the lifetime of a chemoattractant-induced Ga-GTP conformation. FEBS Letters 404, 100-104. (1997).

40. Gomer, R.H. Cell-density sensing: Come on inside and tell us about it. Current Biology 7, R721-R722 (1997).

41. Jain, R., Brazill, D.T., Cardelli, J.T., Bush, J., and Gomer, R.H. Autocrine factors controlling early development. In Dictyostelium-A Model System for Cell and Developmental Biology. (Y. Maeda, K. Inouye, and I. Takeuchi, Eds.) Universal Academy Press, Inc., Tokyo, Japan. pp. 219-234 (1997).

42. Spann, T.P., Brock, D.A., and Gomer, R.H. Shotgun antisense mutagenesis. In Antisense Technologies: A Practical Approach. (Lichtenstein, C. and Nellen, W. Eds.) Oxford University Press, Oxford, UK. pp. 273-279 (1997).

43. Gomer, R.H. Antisense: a key tool for cell and developmental studies in Dictyostelium. In Genetic Engineering, Vol 20: Principles and Methods. (Setlow, J.K. Ed.) Plenum Press, New York, NY pp. 135-141 (1998).

44. Brazill, D.T., Lindsey, D.F., Bishop, J.D., and Gomer, R.H. Cell-density sensing mediated by a G-protein-coupled receptor activating phospholipase C. J. Biol. Chem. 273, 8161-8168 (1998).

45. Lindsey, D.F., Amerik, A., Deery, W.J., Bishop, J.D., Hochstrasser, M., and Gomer, R.H. A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium. J. Biol. Chem. 273, 29178-29187 (1998).

46. Gomer, R.H. Cell Density Sensing in a Eukaryote. ASM News 65:23-29 (1999).

47. Gomer, R.H. Gene identification by shotgun antisense. Methods 18, 311-315 (1999).

48. Brock, D.A. and Gomer, R.H. A cell-counting factor regulating structure size in Dictyostelium. Genes & Development 13, 1960-1969 (1999).

49. Deery, W.J. and Gomer, R.H. A putative receptor mediating cell-density sensing in Dictyostelium. J. Biol. Chem. 274, 34476-34482 (1999).

50. Brazill, D.T., Caprette, D.R., Myler, H.A., Hatton, R.D., Ammann, R.R., Lindsey, D.F., Brock, D.A., and Gomer, R.H. A protein containing a serine-rich domain with vesicle-fusing properties mediates cell cycle-dependent cytosolic pH regulation. J. Biol. Chem. 275, 19231-19240 (2000).

51. Rosin-Bouffay, C., Jang, W., Caprette, D.R., and Gomer, R.H. A precise group size in Dictyostelium is generated by a cell-counting factor modulating cell-cell adhesion. Mol. Cell 6, 953-959 (2000).

52. Azhar, M., Kennady, P.K., Pande, G., Espiritu, M., Holloman, W., Brazill, D., Gomer, R.H., and Nanjundiah, V. Cell cycle phase, cellular Ca²⁺ and development in Dictyostelium discoideum. Int. J. Dev. Bio. 44, 405-414 (2001).

53. Gomer, R.H. Not being the wrong size. Nature Reviews Molecular Cell Biology 2, 48-54 (2001).

54. Tang, L., Ammann, R., Gao, T., and Gomer, R.H. A cell number-counting factor regulates group size in Dictyostelium by differentially modulating cAMP-induced cAMP and cGMP pulse sizes. J. Biol. Chem. 276, 27663-27669 (2001).

55. Brazill, D.T., Meyer, L.R., Hatton, R.D., Brock, D.A., and Gomer, R.H. ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium. J. Cell Sci. 114, 3923-3932 (2001).

56. Tang, L., Gao, T., McCollum, C., Jang, W., Vicker, M.G., Ammann, R.R., and Gomer, R.H. A cell number-counting factor regulates the cytoskeleton and cell motility in Dictyostelium. Proc. Natl. Acad. Sci. USA. 99, 1371-1376 (2002).

57. Sharma S.K., Brock D.A., Ammann R.R., DeShazo T., Khosla M., Gomer R.H., and Weeks G. The Cdk5 homologue, Crp, regulates endocytosis and secretion in Dictyostelium and is necessary for optimum growth and differentiation. Dev. Biol. 247, 1-10 (2002).

58. Brock, D.A., Hatton, R.D., Giurgiutiu, D.-V., Scott, B., Ammann, R., and Gomer, R.H. The different components of a multisubunit cell number-counting factor have both unique and overlapping functions. Development 129, 3657-3668 (2002).

59. Lewis, Z.A., Correa, A., Schwerdtfeger, C., Link, K.L., Xie, X., Gomer, R.H., Thomas, T., Ebbole, D.J., and Bell-Pedersen, D. Overexpression of WHITE COLLAR-1 (WC-1) activates circadian clock-associated genes, but is not sufficient to induce most light-regulated gene expression in Neurospora crassa. Molecular Microbiology 45, 917-31 (2002).

60. Bishop, J.D., Moon, B.C., Harrow, F., Gomer, R.H., Dottin, R.P., and Brazill, D.T. A second UDP glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum. J. Biol. Chem. 277, 32430-32437 (2002).

61. Gao, T., Ehrenman, K., Tang, L., Leippe, M., Brock, D.A., and Gomer, R.H. Cells respond to and bind countin, a component of a multisubunit cell-number counting factor. J. Biol. Chem. 277, 32596-32605 (2002).

62. Deery, W.J., Gao, T., Ammann, R.A., and Gomer, R.H. A single cell-density sensing factor stimulates distinct signal transduction pathways through two different receptors. J. Biol. Chem. 277, 31972-31979 (2002).

63. Jang, W., Chiem, B., and Gomer, R.H. A secreted cell-number counting factor represses intracellular glucose levels to regulate group size in Dictyostelium. J. Biol. Chem. 277, 39202-39208 (2002).

64. Gomer, R.H., Gao, T., Tang, Y., Knecht, D., and Titus, M.A. Cell motility mediates tissue size regulation in Dictyostelium. J. Muscle Res. Cell Motil. 23, 809-815 (2002).

65. Gomer, R.H. and Brazill, D. The versatile Dictyostelium discoideum. Meeting Report: International Dictyostelium Conference 2002. Protist. 154, 5-10 (2003)

66. Brock, D.A., Hatton, R.D., Giurgiutiu, D-V, Scott, B., Jang, W., Ammann, R., and Gomer, R.H. CF45-1, a secreted protein which participates in group size regulation in Dictyostelium. Eukaryotic Cell 2, 788-797 (2003).

67. Ochsner, S.A., Day, A.I., Rugg, M.S., Breyer, R.M., Gomer, R.H., and Richards, J.S. Disrupted function of TNF-a stimulated gene 6 blocks cumulus cell-oocyte complex expansion. Endocrinology. 144,4376-84 (2003).

68. Pilling, D., Buckley, C.D., Salmon, M., and Gomer, R.H. Inhibition of fibrocyte differentiation by serum amyloid P. J Immunology 171, 5537-5546 (2003).

69. Correa, A., Lewis, Z.A., Green, A.V., March, I.J., Gomer, R.H., and Bell-Pedersen, D. Microarray profiling reveals multiple oscillators regulate circadian gene expression in Neurospora. Proc. Natl. Acad. Sci. USA. 100, 13597-13602. (2003)

70. Brock, D.A., Ehrenman, K., Ammann, R., Tang, Y., and Gomer, R.H. Two components of a secreted cell-number counting factor bind to cells and have opposing effects on cAMP signal transduction in Dictyostelium. J. Biol. Chem. 278, 52262-52272 (2003).

71. Ehrenman, K., Yang, G., Hong, W-P., Gao, T., Jang, W., Brock, D.A., Hatton, R.D., Shoemaker, J.D., and Gomer, R.H. Disruption of aldehyde reductase increases group size in Dictyostelium. J. Biol. Chem. 279, 837-847 (2004).

72. Rosin-Bouffay, C., and Gomer, R.H. Comment atteindre la bonne taille. Médecine/Sciences. 20, 219-224 (2004).

73. Gao, T., Knecht, D., Tang, L., Hatton, R.D., and Gomer, R.H. A cell number counting factor regulates Akt/Protein Kinase B to regulate Dictyostelium discoideum group size. Eukaryotic Cell 3, 1174-1185 (2004).

74. Jang, W., and Gomer, R.H. Exposure of cells to a cell-number counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium. Eukaryotic Cell 4, 72-81 (2005).

75. Kolbinger, A., Gao, T., Brock, D., Ammann, R., Kisters, A., Kellermann, J., Hatton, D., Gomer, R.H., and Wetterauer, B. A cysteine-rich extracellular protein containing a PA14 domain mediates quorum sensing in Dictyostelium. Eukaryotic Cell 4, 991-998 (2005).

76. Brock, D.A. and Gomer, R.H. A secreted factor represses cell proliferation in Dictyostelium. Development 132, 4553-4562 (2005).

77. Dallon, J. Jang, W, and Gomer, R.H. Mathematically modeling the effects of counting factor in Dictyostelium discoideum. Mathematical Medicine and Biology. 23, 45-62. (2006).

78. Pilling, D., Tucker, N., and Gomer, R.H. Aggregated IgG inhibits human fibrocyte differentiation. J. Leukocyte Biology, 79, 1242-1251 (2006).

79. de Paula, R.M., Lewis, Z.A., Greene, A.V., Seo, K.S., Morgan, L.W., Vitalini, M.W., Bennett, L., Gomer, R.H., and Bell-Pedersen, D. Two circadian timing circuits in Neurospora crassa cells share components and regulate distinct rhythmic processes. Journal of Biological Rhythms. 21, 159-168 (2006).

80. Pilling, D. and R.H. Gomer. Regulatory Pathways for Fibrocyte Differentiation. In Fibrocytes: New Insights into Tissue Repair and Systemic Fibrosis (R. Bucala, Ed.). World Scientific, Singapore. pp. 37-60 (2006).

81. Jang, W. and Gomer, R.H. A factor in crude cytosol regulates glucose-6-phosphatase activity in crude microsomes to regulate group size in Dictyostelium. J. Biol. Chem. 281, 16377-16383 (2006).

82. Brock, D.A., van Egmond, W.N., Shamoo, Y., Hatton, R.D., and Gomer, R.H. A 60 kDa protein component of the counting factor complex regulates group size in Dictyostelium. Eukaryotic Cell 5, 1532-1538 (2006).

83. Whitney, N., Pearson, L.J., Lunsford, R., McGill, L., Gomer, R.H., and Lindsey, D.F. A putative Ariadne-like ubiquitin ligase is required for Dictyostelium development. Eukaryotic Cell, 5, 1820-1825 (2006).

84. Haudek, S.B., Xia, Y., Huebener, P., Lee, J.M., Carlson, S., Crawford, J.R., Pilling, D., Gomer, R.H., Trial, J., Frangogiannis, N.G., and Entman, M.L. Bone Marrow-derived Fibroblast Precursors Mediate Ischemic Cardiomyopathy in Mice. Proc. Natl. Acad. Sci. USA, 103, 18284-18289.

85. Gao, T, Rosin-Bouffay, C., Hatton, R.D., Tang, L., Brock, D.A., DeShazo, T., Olson, L., Hong, W-P., Jang, W., and Gomer, R.H. A cell-number counting factor regulates levels of a novel protein, SslA as part of a group-size regulation mechanism in Dictyostelium. Submitted.

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Patent Applications

US Provisional Patent Applications

US 60/436,046 (12/23/02) - Methods of Detecting Fibrocyte Differentiation, Methods of Detecting, Preventing and Treating Fibrosing Diseases

US 60/436,027 (12/23/02) - Methods of Detecting the Inhibition of Fibrocyte Formation, Methods of Enhancing Fibrocyte Formation and Wound Healing

US 60/515,776 (10/30/03) - Inhibition of Fibrocyte Differentiation by Serum Amyloid P

US 60/519,467 (11/12/03) - Methods of Detecting the Inhibition of Fibrocyte Formation, Methods of Enhancing Fibrocyte Formation and Wound Healing

US 60/525,175 (11/26/03) - Methods of Detecting Fibrocyte Differentiation, Methods of Detecting, Preventing and Treating Fibrosing Diseases

Patent Cooperation Treaty (PCT) patent applications

PCT/US03/40957 published as WO 04/058292 (12/22/03) - Methods and Compositions for Suppressing Fibrocyte Differentiation and Methods for Suppressing Fibrosis

PCT/US03/41183 published as WO 04/059318 (12/22/03) - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods of Compositions for Enhancing Fibrocyte Formation

PCT/US06/005229 (2/15/2006) - Compositions and Methods for Suppressing Fibrocyte Differentiation

Continuation-in-part applications

US 11/158,966 filed 6/22/05 - published as US 2005 0238620 CIP of PCT/US03/40957 - Compositions and Methods for Suppressing Fibrocyte Differentiation From Monocytes and for Detecting Fibrocyte Differentiation

US 11/158,723 filed 6/22/05 - published as US 2006 0002938 CIP of PCT/US03/41183 - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods and Compositions for Enhancing Fibrocyte Formation

US 11/535636 filed 9/27/06 - CIP of US 11/158,966 - Compositions and Methods for Suppressing Fibrocytes and for Detecting Fibrocyte Differentiation

US 11/535649 filed 9/27/06 - CIP of US 11/158,966 and PCT /US06/005229 - Compositions and Methods for Suppressing Fibrocytes

Foreign patent applications

Europe - EP 03814319 published from PCT/US03/40957 (12/22/03) - Methods and Compositions for Suppressing Fibrocyte Differentiation and Methods for Suppressing Fibrosis

Europe - EP 03800146 published from PCT/US03/41183 (12/22/03) - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods of Compositions for Enhancing Fibrocyte Formation

Australia - AU 2003 300266 from PCT/US03/40957 (12/22/03) - Methods and Compositions for Suppressing Fibrocyte Differentiation and Methods for Suppressing Fibrosis

Australia - AU 2003 299873 from PCT/US03/41183 (12/22/03) - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods of Compositions for Enhancing Fibrocyte Formation

Canada - CA 2509241 from PCT/US03/40957 (12/22/03) - Methods and Compositions for Suppressing Fibrocyte Differentiation and Methods for Suppressing Fibrosis

Canada - CA 509392 from PCT/US03/41183 (12/22/03) - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods of Compositions for Enhancing Fibrocyte Formation

Japan - JP 2004 563958 from PCT/US03/40957 (12/22/03) - Methods and Compositions for Suppressing Fibrocyte Differentiation and Methods for Suppressing Fibrosis

Japan - JP 2004 564024 from PCT/US03/41183 (12/22/03) - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods of Compositions for Enhancing Fibrocyte Formation

Israel - IL 169258 from PCT/US03/41183 (12/22/03) - Methods of Detecting the Inhibition of Fibrocyte Formation and Methods of Compositions for Enhancing Fibrocyte Formation