Cytochrome Oxidase from Paracoccus Denitrificans:
Iwata et al Nature 376 660-669 (1995).
Courtesy of So IWATA.
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Side View of Complete Enzyme
From left to right we have:
Subunit III (in blue) with an embedded phospholipid.
Subunit IV (green, unique to this enzyme)
Subunit I (yellow)
Subunit II (purple)
Antibody fragment (cyan) used to drive crystallization.
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Top View of Full Enzyme emphasizinhg helices and beta strands
Helices and strands are identified by Roman and Arabic numerals respectively.
Color Code is :
Subunit III: blue.
Subunit IV: green.
Subunit I: yellow.
Subunit II: purple.
Antibody fragment is omitted.
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All of Subunit II showing the two transmembrane helices
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Upper Portion of Subunit II emphasizing beta strands
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The Copper A Center in subunit II
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All of Subunit I from Side
The main features are 11 transmembrane helices, 1 interupted helix (VII)
and two helical connections (III-IV) and (IX-X) lying on the
membrane surface. Heme a is red, Heme a3 is cyan and CuB is blue.
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A schematic of the 28 TM helices of bovine enzyme;
note the unusual arrangement in subunit I which resemble
a propellor.
Subunit I from Top: Compare with the schematic above
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The environment of cytochrome a
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The Cytochrome a3-CuB Binuclear center
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