Publications of Peter Brzezinski and co-workers

Brzezinski, P. & Malmstrom, B.G. (1985) The reduction of cytochrome c oxidase by carbon monoxide, FEBS Lett. 187, 111-114. Brzezinski, P., Thornstrom, P.-E. & Malmstrom, B.G. (1986) The rate-limiting step and nonhyperbolic kinetics in the oxidation of ferrocytochrome c catalyzed by cytochrome c oxidase, FEBS Lett. 194, 1-5. Brzezinski, P. & Malmstrom, B.G. (1986) Electron-transport-driven proton pumps display nonhyperbolic kinetics: Simulation of the steady-state kinetics of cytochrome c oxidase, Proc. Natl. Acad. Sci. USA 83, 4282-4286. Fabian, M., Thornstrom, P.-E., Brzezinski, P. & Malmstrom, B.G. (1987) Two- electron reduction is required for rapid internal electron transfer in resting, pulsed and oxygenated cytochrome c oxidase, FEBS Lett. 213, 396-400. Brzezinski, P. & Malmstrom, B.G. (1987) The mechanism of electron gating in proton pumping cytochrome c oxidase: the effect of pH and temperature on internal electron transfer, Biochim. Biophys. Acta. 894, 29-38. Thornstrom, P.-E., Brzezinski, P. Fredriksson, P.-O. & Malmstrom, B.G. (1988) Cytochrome c oxidase as an electron-transport-driven proton pump: pH dependence of the reduction levels of the redox centers during turnover, Biochemistry 27, 5441-5447. Brzezinski, P., Malmstrom, B.G., Lorentzon, P. & Wallmark, B. (1988) The catalytic mechanism of gastric (H+ + K+)-ATPase: simulation of pre-steady-state and steady-state kinetic results, Biochim. Biophys. Acta 942, 215-219. Oliveberg, M., Brzezinski, P. and Malmstrom, B.G. (1989) The effect of pH and temperature on the reaction of fully reduced and mixed-valence cytochrome c oxidase with dioxygen, Biochim. Biophys. Acta 977, 322-328. Brzezinski, P. (1990) A reaction cycle for cytochrome c oxidase as an electron- transport-driven proton pump: the effect of electrochemical potential and slips, J. Biol. Phys. 17: 245-263. Hallen, S, Oliveberg, M. and Brzezinski, P., (1993) Light-induced structural changes in Cytochrome c Oxidase: Measurements of electrogenic events and absorbance changes, FEBS Lett. 318, 134-138. Hallen, S., Brzezinski, P and B.G. (1994) Internal electron transfer in Cytochrome c oxidase is coupled to the protonation of a group close to the bimetallic site, Biochemistry, 33, 1467-1472. Hallen, S and Brzezinski, P. (1994) Structural Rearrangements Following Pulsed Illumination of Cytochrome c Oxidase: Implication for the Mechanism of Electron and Proton Gating, Biochim. Biophys. Acta, 1184, 207-218. Peter Brzezinski, Mikael Sundahl, Pia Adelroth, Michael T. Wilson, Bassam El- Agez, Pernilla Wittung, Bo G. Malmstrom (1995) Triplet-state quenching in complexes between Zn-cytochrome c oxidase or its CuA domain: evidence that CuA is the primary site of electron entry Biophys. Chem. 54, 191-197. Pia Adelroth, Peter Brzezinski and Bo G. Malmstrom (1995) Internal electron transfer in Cytochrome c oxidase from Rhodobacter sphaeroides. Biochemistry, 34, 2844-2849. David M. Mitchell, Roland Aasa, Pia Adelroth, Peter Brzezinski, Robert B. Gennis and Bo G. Malmstrom (1995) EPR Studies of Wildtype and Several Mutants of Cytochrome c Oxidase from Rhodobacter sphaeroides: Glu286 is not a Bridging Ligand in the Cytochrome a3-CuB Center. FEBS Lett. 374, 371-374. David M. Mitchell, Pia Adelroth, Jonathan P. Hosler, John R. Fetter, Peter Brzezinski, Michelle A. Pressler, Bo G. Malmstrom, James O. Alben, Gerald T. Babcock, Robert B. Gennis, and Shelagh Ferguson-Miller (1996) A Ligand- Exchange Mechanism of Proton Pumping Involving Tyrosine-422 of Subunit I of Cytochrome Oxidase is Ruled Out. Biochemistry 35, 824-828. Peter Brzezinski (1996) Internal Electron-Transfer Reactions in Cytochrome c Oxidase. Biochemistry 35, 5611-5615. Pia Adelroth, Hkan Sigurdson, Stefan Hallen and Peter Brzezinski (1996) Kinetic coupling between electron and proton transfer in cytochrome c oxidase: Simultaneous measurements of flash-induced absorbance and conductance changes, Proc. Natl. Acad. Sci. USA, 93, 12292-12297. David M. Mitchell, John R. Fetter, Denise A. Mills, Pia Adelroth, Michelle A. Pressler, Youngkyou Kim, Roland Aasa, Peter Brzezinski, Bo G. Malmstrom, James O. Alben, Gerald T. Babcock, Shelagh Ferguson-Miller and Robert B. Gennis (1996) Site-Directed Mutagenesis of residues Lining a Putative Proton- Transfer Pathway in Cytochrome c Oxidase from Rhodobacter sphaeroides. Biochemistry 35, 13089-13093. Margareta Svensson-Ek, Jeffrey W. Thomas, Robert B. Gennis, Thomas Nilsson and Peter Brzezinski (1996) Kinetics of Electron and Proton Transfer During the Reaction of Oxygen with Wild Type and Helix VI Mutants of Cytochrome bo3 with oxygen. Biochemistry, 35, 13673-13680. Shun Hirota, Margareta Svensson, Pia Adelroth, Nobuhito Sone, Thomas Nilsson, Bo G. Malmstrom and Peter Brzezinski (1996) A flash-photolysis study of the reactions of a caa3-type cytochrome oxidase with dioxygen and carbon monoxide, J. Bioenergetics and Biomembranes 28, 497-503. Margareta Svensson-Ek & Peter Brzezinski (1997) Oxidation of Ubiquinol by Cytochrome bo3 from Escherichia coli: Kinetics of Electron and Proton Transfer Biochemistry 36, 5425-5431. Pia Adelroth, David M. Mitchell, Robert B. Gennis and Peter Brzezinski (1997) Factors determining electron-transfer rates in cytochrome c oxidase: studies of the FQ(I-391) mutant of Rhodobacter sphaeroides. Biochemistry 36, 11787-11796. P. Brzezinski and M.T. Wilson (1997) Photochemical Electron Injection into Redox- Active Proteins Proc. Natl. Acad. Sci. USA 94, 6176-6179. P. Brzezinski & P. Adelroth (1997) Proton-Transfer Pathways in Cytochrome c Oxidase. Invited review for a special issue on cytochrome c oxidase in J. Bioenergetics and Biomembranes Pia Adelroth, Margareta Svensson-Ek, David M. Mitchell, Robert B. Gennis, and Peter Brzezinski (1997) Glutamate 286 in cytochrome aa3 from Rhodobacter sphaeroides is involved in proton uptake during the reaction of the fully reduced enzyme with oxygen. Biochemistry 36, 13824-13829.. Pia Adelroth, Robert B. Gennis and Peter Brzezinski (1997) The Role of the Pathway through K(I-362) in Proton Transfer in Cytochrome c Oxidase from R. sphaeroides. Biochemistry In Press. Brzezinski, P. and Adelroth, P. (1997) Proton-Controlled Electron Transfer in Cytochrome c Oxidase: Functional Role of the Pathways through Glu 286 and Lys 362 Acta Physiologica Scandinavica., In Press.